Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers

Introduction: Medications used to treat oral ulcers include corticosteroids, anesthetics, and antihistamines. These can be as gels, mouthwashes, pastes, ointments, etc. Diphenhydramine hydrochloride (DPH) has local anesthetic properties that help the aphthae. One of drawbacks delivery transmucosal is quick turnaround time gel, a mucous form located on epithelial film surface. Methods: Therefore, it seems preparation carrier characteristics adhesive mucus increase duration drug retention To solve this problem, mesoporous silica nanoparticles (MSNPs) were synthesized functionalized with amino thiol groups suggested system delivery. The structure MSNPs investigated by dynamic light scattering (DLS), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), thermal gravimetric analysis (TGA), Fourier transform infrared (FTIR), nitrogen adsorption-desorption isotherms (BET). Results: Our outcomes indicated average sizes bare (MSN), modified (MSN-NH2), (MSN-SH) obtained 611, 655, 655 nm respectively pore size MSN, MSN-NH2, MSN-SH about 2.42 nm, 2.44 respectively, according BJH (Barrett-Joyner-Halenda) distribution. release kinetics DPH from carriers evaluated. Conclusion: Eventually, mucoadhesive study DPH-loaded particles investigated. Also, exhibited high capacity for buccal mucosa compared MSN-NH2 MSN.